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(CNN)President Donald Trump's targeted killing of Iran's ruthless intelligence chief adds up to his most dangerous gamble yet with other peoples' lives and his own political fate.

By killing Qasem Soleimani in Iraq, Trump committed the United States to a risky open conflict that at best could stop short of all-out war with Iran that could cause national security and economic shocks in the United States and across the globe.

Starting right now, and given Iran's easy access to soft targets, the Middle East and even Europe suddenly look a lot less safe for Americans, including US troops Trump may be even more tempted to haul home.

Two days into his re-election year, Trump -- who rails against Middle Eastern entanglements -- has plunged the United States into another one, with vast and unknown consequences. It challenges a presidency that is already alienating half of his country, following his impeachment and unrestrained behavior in office. Trump may find it impossible to rally the nation behind him to weather the crisis. He has also scrambled strategic and moral expectations of the United States -- ordering the killing of a senior foreign leader of a nation with whom the US is not formally at war -- albeit an official regarded by Washington as a terrorist.

The reverberations of his act on Thursday will last for years.